فرمولاسیون و ارزیابی فراورده ژل شونده در محل از فلوکونازول

Background and purpose: In Situ Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The aim of this study was to formulate and evaluate in situ oral topical gels of fluconazole based on concept of pH triggered system. Materials and methods: An in situ gel system consisting of carbopol 934, hydroxypropyl methylcellulose and sodium alginate was used in different concentrations to prolong the release of fluconazole. Fluconazole was added to polymer’s solution after being hydrated. Formulations were evaluated for gelling capacity, physical stability, pH, drug content, viscosity and in vitro release. Results: The use of carbopol as in situ gel forming agent was substantiated by the property to transform into stiff gels when the pH was raised. The gelling capacity, pH and drug content of formulations were found to be satisfactory. The viscosity range was from 60 to 104 centipoise in shear rate of 20 rpm. The formulations showed pseudoplastic flow and were able to release the drug slowly. The formulations showed no significant changes in different condition during the period of 90 days and were found to be stable. Conclusion: The ideal formulation can be utilized for the sustained release property.